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Objective The aim of this study is to determine whether the SUMO4 M55 V polymorphism is associated with susceptibility to type 2 diabetes mellitus(T2DM).Methods A meta-analysis was performed to detect the potential association of the SUMO4 M55 V polymorphism and susceptibility to T2 DM under dominant,recessive,co-dominant(homogeneous and heterogeneous),and additive models.Results A total of eight articles including 10 case-control studies,with a total of 2932 cases and 2679 controls,were included in this meta-analysis.The significant association between the SUMO4 M55 V polymorphism and susceptibility to T2 DM was observed in the dominant model(GG + GA versus AA:OR = 1.21,95% CI = 1.05-1.40,P = 0.009),recessive model(GG versus GA + AA:OR = 1.29,95% CI = 1.07-1.356,P = 0.010),homozygous model(GG versus AA:OR = 1.41,95% CI = 1.06-1.56,P = 0.001),and additive model(G versus A:OR = 1.18,95% CI = 1.08-1.29,P = 0.001),and marginally significant in the heterozygous model(GA versus AA:OR = 1.16,95% CI = 0.98-1.36,P = 0.080).In subgroup analyses,significant associations were observed in the Chinese population under four genetic models excluding the heterozygous model,whereas no statistically significant associations were observed in the Japanese population under each of the five genetic models.Conclusion The meta-analysis demonstrated that the G allele of the SUMO4 M55 V polymorphism could be a susceptible risk locus to T2 DM,mainly in the Chinese population,while the association in other ethnic population needs to be further validated in studies with relatively large samples.
Objective The aim of this study is to determine whether the SUMO4 M55 V polymorphism is associated with susceptibility to type 2 diabetes mellitus (T2DM). Methods A meta-analysis was performed to detect the potential association of the SUMO4 M55 V polymorphism and susceptibility to T2 DM under dominant, recessive, co-dominant (homogeneous and heterogeneous), and additive models. Results A total of eight articles including 10 case-control studies, with a total of 2932 cases and 2679 controls, were included in this meta-analysis. The significant association between the SUMO4 M55 V polymorphism and susceptibility to T2 DM was observed in the dominant model (GG versus GA versus AA: OR = 1.21, 95% CI = 1.05-1.40, P = 0.009) (GG versus AA: OR = 1.41, 95% CI = 1.06-1.56, P = 0.001), and additive model (G versus AA: OR = 1.29, 95% CI = 1.07-1.356, A: OR = 1.18, 95% CI = 1.08-1.29, P = 0.001), and marginally significant in the heterozygous model (GA versus AA: OR = 1.16 , 95% CI = 0.98-1.36, P = 0.080) .In subgroup analyzes, significant associations were observed in the Chinese population under four genetic models excluding the heterozygous model, five genetic models. Confluence The meta-analysis demonstrated the G allele of the SUMO4 M55 V polymorphism could be a susceptible risk locus to T2 DM, mainly in the Chinese population, while the association in other ethnic population needs to be further validated in studies with relatively large samples.