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目的研究戊四氮(PTZ)点燃猫癫核医学科形成过程中局部脑血流和葡萄糖代谢变化特征,确定癫核医学科形成相关脑区及其在癫核医学科形成过程中的作用。方法用单光子发射计算机断层显像(99mTcECDSPECT)和正电子发射断层显像(18FDGPET)观察10只PTZ点燃雄性家猫癫核医学科形成过程中,不同行为和脑电特征时期的局部脑血流和葡萄糖代谢的动态变化规律,以感兴趣区(ROI)法对各脑区的葡萄糖代谢作半定量分析,综合分析其相互关系。结果在点燃过程中,猫的部分脑区出现持续高血流灌注和高葡萄糖代谢。临床表现为发作性四肢强直以前,猫的前脑区(额区、基底结)出现高血流灌注和高葡萄糖代谢;出现全面性强直阵挛发作后,高血流灌注和高葡萄糖代谢区逐渐转移至丘脑、海马和梨状皮质。结论PTZ点燃过程中,大脑高血流灌注和高葡萄糖代谢区可能为癫核医学科形成相关脑区。随着抽搐程度的加重,高血流灌注和葡萄糖代谢区从大脑额区向后,向深部(主要集中于丘脑、海马和梨状皮质)转移。
Objective To investigate the changes of local cerebral blood flow and glucose metabolism during PTZ-induced cats epilepsy, and to determine the role of PTZ-related brain regions in the formation of epileptic medicine. Methods Single photon emission computed tomography (99mTcECDSPECT) and positron emission tomography (18FDGPET) were used to observe the changes of regional cerebral blood flow during 10 behavioral and electroencephalographic (EEG) The dynamic changes of glucose metabolism were analyzed by semi-quantitative analysis of the glucose metabolism in each brain region by ROI method, and the correlation was analyzed comprehensively. Results In the process of ignition, part of the brain area of the cat showed continuous high perfusion and high glucose metabolism. Prior to the onset of an episode of limb stiffness, forebrain (forehead, basal ganglia) in cats developed hyperperfusion and hyperglycemia; after a complete tonic-clonic seizure, hyperperfusion and glucose-metabolizing regions gradually developed Transfer to the thalamus, hippocampus and piriform cortex. Conclusions During the PTZ ignition, high cerebral perfusion and high glucose metabolism may be related to the formation of relevant brain regions in the epileptic medicine department. With the aggravating degree of seizures, high perfusion and glucose metabolism area from the brain frontal area to the deep, mainly concentrated in the thalamus, hippocampus and piriform cortex transfer.