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晶状体蛋白包括酶类晶状体蛋白和非酶类晶状体蛋白,对维持晶状体透明性具有重要作用.目前研究发现角膜中也存在晶状体蛋白,在角膜透明性及眼部正常结构稳定性的维持中起到重要作用.角膜晶状体蛋白指的是包括酶类晶状体蛋白在内的、一类具有酶及结构组成双重功能、具有物种特异性的水溶性蛋白.人类角膜晶状体蛋白主要包括乙醛脱氢酶(ALDH)和转酮醇酶(TKT).这些角膜晶状体蛋白在角膜组织中可通过结构改变吸收紫外线,减少正常组织的损伤,也可通过降解脂质过氧化反应中产生的有毒醛类,抗氧化作用保护眼正常结构的稳定性.同时,角膜晶状体蛋白也在角膜透明性的维持过程中发挥重要作用.此外,部分角膜晶状体蛋白还参与到细胞周期的调控.本文就角膜晶状体蛋白的概念、种类、结构、分布及作用等行为学研究的现状及进展进行综述.“,”Crystallin plays an important role in the maintenance of lens transparency,which can be divided into enzymatic cyrstallin and non-enzymatic crystallin.Recent researches showed that identical proteins,mainly the enzymatic crystallin,also existed in the cornea,which was important to maintain corneal transparency and normal structural stability of the eye.Corneal crystallin refers to a kind of water soluble protein of species specificity including enzymes crystallin,which has both function of enzymes and structure formation.Human corneal crystallin mainly consists of two kinds:aldehyde dehydrogenase (ALDH) and transketolase (TKT).Corneal crystallin can protect the inner ocular tissues from ultraviolet radiation induced damage through its specific conformation to absorb ultraviolet,and act as enzyme to metabolize toxic aldehydes,scavenging reactive oxygen species,thus maintaining corneal transparency.Besides,the presence of some corneal crystallin in nuclear suggests a role in cellular growth regulation.This article aimed to review the current research and progress in the concept,category,structure,distribution and function of corneal crystallin.