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患者,女,46岁,因上呼吸道感染,伴发热,于2009年5月入院。入院体验:T38.8℃,P 90次/min;R 20次/min,BP110/72 mmHg;WBC 13.2×10~9L~-1,N:82%,L:7%。该患者身体健康,有青霉素过敏史。故给予注射用克林霉素磷酸脂0.6g加入100ml的0.9%氯化钠注射液ivd,bid。给药后约10min,患者四肢皮肤出现红斑,并伴有瘙痒,考虑为克林霉素磷酸酯所致过敏反应,立即停药,并给予异丙嗪25mgim,氯苯那敏片8mg口服,患者症状逐渐减轻并皮疹消失。讨论:克林霉素磷酸酯为化学半合成克林霉素衍生物,
The patient, female, 46 years old, was admitted to hospital in May 2009 due to upper respiratory tract infection and fever. Admission experience: T38.8 ℃, P90times / min; R20 times / min, BP110 / 72mmHg; WBC13.2 × 10 ~ 9L ~ -1, N: 82%, L: 7%. The patient is healthy and has a history of penicillin allergy. Therefore, injection of clindamycin phosphate 0.6g added 100ml of 0.9% sodium chloride injection ivd, bid. Approximately 10 minutes after the administration, patients with erythema on the skin of the extremities and pruritus were considered to be allergic reactions caused by clindamycin phosphate, immediate withdrawal, and promethazine 25mgim, chlorpheniramine tablets 8mg orally, patients Symptoms gradually reduce and the rash disappears. Discussion: Clindamycin phosphate is a chemical semi-synthetic clindamycin derivative,