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目的本文通过监测感染新生儿血清中可溶性细胞间黏附分子-1(sICAM-1)和C反应蛋白(CRP)的水平,评价其在新生儿败血症诊断和治疗中的意义。方法在治疗前对比38例新生儿败血症患儿与32例非感染组病例血中的sICAM-1和CRP水平,在抗菌治疗后3 d和10 d分别再次检测sI-CAM-1和CRP水平,研究其相对治疗前的变化。结果治疗前败血症的患儿血清中CRP和sICAM-1的水平与对照组相比均显著升高(P<0.001),治疗后3 d和10 d,血清中CRP和sICAM-1的水平均比治疗前显著下降,与CRP(P=0.01)相比sICAM-1下降更为显著(P<0.001)。结论联合检测血清CRP和sICAM-1对新生儿败血症的早期诊断和判断抗菌治疗的疗效均有重要提示作用。
Objective To evaluate the significance of serum soluble intercellular adhesion molecule-1 (sICAM-1) and C-reactive protein (CRP) levels in neonates with neonatal sepsis and their significance in the diagnosis and treatment of neonatal sepsis. Methods The levels of sICAM-1 and CRP in 38 children with neonatal sepsis and 32 non-infected patients before treatment were compared. The levels of sICAM-1 and CRP were detected again 3 and 10 days after antibacterial treatment, Study its relative changes before treatment. Results Serum levels of CRP and sICAM-1 in pretreatment sepsis patients were significantly higher than those in control group (P <0.001). The levels of CRP and sICAM-1 in serum were significantly higher on the 3rd and 10th day after treatment The level of sICAM-1 was significantly lower than that of CRP (P = 0.01) before treatment (P <0.001). Conclusions Combined detection of serum CRP and sICAM-1 may play an important role in the early diagnosis of neonatal sepsis and judging the efficacy of antibacterial therapy.