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本文应用微量荧光法和放免法测定了135例新生儿硬肿症患儿血清维生素E（VE）和红细胞内超氧化物歧化酶（RBC－SOD）。结果显示：新生儿硬肿症血清VE浓度和RBC－SOD含量均明显低于正常对照（P＜0．01），且随着硬肿程度的增加而降低。经治疗硬肿消退时，血清VE浓度较治疗前稍有下降，两者无统计学差异（P＞0．05）；RBC－SOD含量明显增加，但仍低于正常对照（P＜0．05），提示新生儿硬肿症抗氧化能力不足，进一步探讨了血清VE和RBC-SOD降低的可能原因，建议应用抗氧化剂治疗，减轻脂质过氧化损伤，降低病死率。
In this paper, serum vitamin E (VE) and erythrocyte superoxide dismutase (RBC-SOD) were measured in 135 neonates with sclerodema by fluorescence and radioimmunoassay. The results showed that serum VE concentration and RBC-SOD content in neonatal scleredema were significantly lower than those in normal control (P <0.01), and decreased with the degree of sclerosis. After treatment of sclerosis subsided, serum VE concentration decreased slightly compared with before treatment, there was no significant difference (P> 0.05); RBC-SOD content increased significantly, but still lower than the normal control (P <0.05 ), Suggesting that neonatal scleredemia antioxidant capacity is not enough to further explore the serum VE and RBC-SOD may reduce the possible causes, the proposed application of antioxidants, reduce lipid peroxidation damage and reduce mortality.