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目的:对益气滋阴、疏肝健脾、清热通络法治疗2型糖尿病进行临床研究。方法:将80例患者,采用单盲法随机分为两组,在原用口服降糖西药种类、剂量不变的此基础上,治疗组50例加用自制十三味玉泉丸口服;对照组30例加用参芪降糖胶囊口服。12周后观察两组疗效、血糖、血脂变化及用药安全性。结果:治疗组总有效率90.0%,优于对照组70%(P<0.05);治疗组P2hBG、HbA1 C比对照组下降更明显(P<0.01);治疗组血脂改善优于对照组(P<0.05或P<0.01);两组患者治疗过程中未见明显不良反应,检测安全指标均无明显变化。结论:益气滋阴、疏肝健脾、清热通络法治疗2型糖尿病不仅可以明显降低患者的FBG、P2hBG、HbA1C,还能很好地改善临床症状,调整患者血脂,而且使用安全。
Objective: To study the clinical effects of qi and nourishing yin, soothing liver and invigorating the spleen, clearing heat and clearing collaterals on type 2 diabetes mellitus. Methods: Eighty patients were randomly divided into two groups by single-blind method. On the basis of the original oral administration of western medicine with the same dosage, 50 cases in the treatment group were treated with the homemade Shisan Wei Yu Quan Wan; the control group 30 Example plus Shenqi hypoglycemic capsules oral. After 12 weeks, the curative effect, blood glucose, blood lipid changes and medication safety were observed. Results: The total effective rate was 90.0% in the treatment group, which was better than 70% in the control group (P <0.05). P2hBG and HbA1 C in the treatment group decreased more significantly than those in the control group (P <0.01) <0.05 or P <0.01). No significant adverse reactions were observed in the two groups of patients during the treatment, and no significant changes in safety indicators were detected. Conclusion: The therapy of invigorating qi and nourishing yin and invigorating the spleen and invigorating the spleen and removing heat and clearing the collaterals can not only obviously reduce the FBG, P2hBG and HbA1C in patients, but also improve the clinical symptoms, adjust the blood lipids in patients and make it safe to use.