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目的探讨在妊娠期高血压疾病患者胎盘组织中表皮生长因子受体(EGFR)的表达与病因关系。方法通过免疫组织化学方法检测妊娠期高血压疾病患者64例(妊娠期高血压组21例,子痫前期轻度组23例,重度组20例)及健康足月孕妇20例(对照组)胎盘组织中EGFR蛋白的表达情况。结果妊娠期高血压疾病患者胎盘组织中表皮生长因子受体(EGFR)在妊娠期高血压组表达水平为56.174±3.1020,子痫前期轻度组患者中为78.6844±2.6713,两组比较,差异有统计学意义(t=18.73,P=0.0001);EGFR在子痫前期重度组患者中表达为94.2090±6.8352,与子痫前期轻度组比较,差异有统计学意义(t=11.37,P<0.0001)。结论妊娠期高血压疾病患者胎盘组织中EGFR的蛋白表达升高和过度激活,可能在妊娠期高血压疾病发生发展中起重要作用。
Objective To investigate the relationship between the expression of epidermal growth factor receptor (EGFR) and placenta in patients with gestational hypertension. Methods Sixty-four patients with gestational hypertension (21 cases of gestational hypertension, 23 cases of mild preeclampsia and 20 cases of severe preeclampsia) and 20 healthy term pregnant women (control group) were examined by immunohistochemistry. EGFR protein expression in tissues. Results The expression of epidermal growth factor receptor (EGFR) in placental tissue of patients with gestational hypertension was 56.174 ± 3.1020 in gestational hypertension group and 78.6844 ± 2.6713 in mild preeclampsia group. There was significant difference between the two groups (T = 18.73, P = 0.0001). The expression of EGFR in patients with severe preeclampsia was 94.2090 ± 6.8352, which was significantly different from that in mild preeclampsia (t = 11.37, P <0.0001) ). Conclusion The high and overexpression of EGFR in placenta of patients with gestational hypertension may play an important role in the development of hypertensive disorder complicating pregnancy.