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自1972年Kerr发现自然界存在细胞凋亡现象以来,人们对细胞凋亡与肿瘤的关系进行了大量研究,发现细胞凋亡与肿瘤发生、消退密切相关,因此有关肿瘤凋亡的研究倍受关注。业已证明,放射治疗、化疗以及热疗等治疗肿瘤的机制是诱导肿瘤细胞发生凋亡,本文就有关鼻咽癌细胞凋亡方面的研究作一综述。 1 肿瘤发展中细胞凋亡的作用细胞有增殖、分化和凋亡三方面的特性。在正常情况下,三者相互协调,共同调节,处于一种平衡状态。长期以来,人们侧重于肿瘤增殖活性和分化特征方面的研究,而对肿瘤细胞凋亡的研究相对较少。然而,近来研究表明,细胞凋亡(apoptosis)是细胞死亡的基本形式之一,不仅在正常的
Since Kerr discovered the phenomenon of apoptosis in nature in 1972, a great deal of studies have been done on the relationship between apoptosis and tumor. It is found that apoptosis is closely related to the occurrence and regression of tumor. Therefore, the research on tumor apoptosis has drawn much attention. It has been proved that radiation therapy, chemotherapy and hyperthermia treatment of cancer mechanisms is to induce apoptosis of tumor cells, this article on the apoptosis of nasopharyngeal carcinoma cells are reviewed. Apoptosis in tumor development Cell proliferation, differentiation and apoptosis in three aspects. Under normal circumstances, the three are in harmony with each other and jointly adjusted at a balance. For a long time, people focused on tumor proliferation activity and differentiation characteristics of the study, and the study of tumor cell apoptosis is relatively small. However, recent studies have shown that apoptosis is one of the basic forms of cell death, not only in normal