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目的探讨GnRH-a及宫腔镜检查在反复种植失败(RIF)中的疗效。方法选取2015年1月-2016年1月本中心行冻融胚胎移植后反复种植失败患者共63例,分为A(GnRH-a)、B(宫腔镜)、C(GnRH-a联合宫腔镜)三组,其中A组23例,B组24例,C组16例。观察三组患者移植日内膜厚度、种植率、妊娠率及流产率情况。结果黄体酮日C组内膜厚度(9.26±1.02)略低于A(9.33±0.74)、B(9.43±1.26)两组;A组种植率及妊娠率低于B、C组;与A、B组相比,C组妊娠率(50%VS 43.47%、45.83%)最高,流产率(25%VS 30%、27.27%)最低,但差异均无统计学意义(P>0.05)。结论反复种植失败患者联合应用GnRH-a及宫腔镜检查也许能获得更好的临床效果。
Objective To investigate the efficacy of GnRH-a and hysteroscopy in repeated implant failure (RIF). Methods A total of 63 patients with failed implantation after frozen-thawed embryo transfer in our hospital from January 2015 to January 2016 were divided into A (GnRH-a), B (hysteroscopy), C (GnRH-a) Endoscopic) three groups, including 23 cases in group A, 24 cases in group B, 16 cases in group C. The intima thickness, implantation rate, pregnancy rate and abortion rate of the three groups were observed. Results The endometrial thickness of Progesterone Day C group (9.26 ± 1.02) was slightly lower than that of A (9.33 ± 0.74) and B (9.43 ± 1.26) groups. The implantation rate and pregnancy rate of group A were lower than those of group B and C Compared with group B, pregnancy rate (50% vs 43.47%, 45.83%) in group C was the highest, while abortion rate was the lowest (25% vs 30%, 27.27%), but the difference was not statistically significant (P> 0.05). Conclusions Repeated implant failure patients combined with GnRH-a and hysteroscopy may be able to get better clinical results.