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应用香豆素治疗下肢象皮肿56例,每人每日服400mg,连服367d,不绑扎患肢。56条腿治疗中与治疗毕腿径平均比治前分别缩小4.2%和6.5%,还原率治疗中平均为43.4%,治毕平均为68.1%。56例患者治疗半年时基本治愈率为25.0%,显效与有效率分别为7.1%和67.9%;治毕时基本治愈率为28.6%,显效与有效率分别为12.5%和58.9%。对照组病人服安慰剂后均不见好转,且有5例患肢继续增粗。停服香豆素后半年随访54例,疗效巩固,腿径比治前缩小7.2%。长期口服香豆素并无不良反应,用于治疗丝虫性象皮肿优于以往试用的其他疗法,患者在家服药不影响劳动生产,值得推广试用。
Coumarin treatment of lower extremity elephantiasis 56 cases, each serving 400mg daily, and even served 367d, do not tie the limbs. 56 legs in the treatment of the average diameter of the treatment and treatment than before treatment were reduced by 4.2% and 6.5%, respectively, the reduction rate of treatment was 43.4%, an average of 68.1%. Sixty-six patients achieved a basic cure rate of 25.0% and effective and effective rates of 7.1% and 67.9% respectively after six months of treatment. The cure rate was 28.6% and the effective and effective rates were 12.5% and 58.9% respectively. Patients in the control group received no improvement after taking placebo, and 5 patients continued to thicken. After taking coumarin for half a year follow-up 54 cases, the effect of consolidation, leg diameter reduced by 7.2% than before treatment. Long-term oral coumarin and no adverse reactions, for the treatment of filarial elephantiasis better than the previous trial of other therapies, patients taking medicine at home does not affect labor and production, it is worth promoting the trial.