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胱抑素C(CystatinC,CysC),是上世纪80年代中期从血清中分离出来的一种半胱氨酸蛋白酶抑制剂,也被称作半胱氨酸蛋白酶抑制剂C、胱抑素C、γ2痕迹蛋白或后γ球蛋白[1]。为Cystatin超家族成员。研究发现,它与肾小球滤过率(GFR)密切相关,肾小球滤过率(GFR)是目前综合评估肾功能的最好指标。因此CysC成为评价早期肾功能损伤的一个敏感性好、特异性高的指标。现就其结构、测定及评价肾功能等方面进行综述。
Cystatin C (CysC), a cysteine protease inhibitor isolated from serum in the mid-1980s, is also known as cysteine proteinase inhibitor C, Cystatin C, γ2 trace protein or post-gamma globulin [1]. Cystatin superfamily member. The study found that it is closely related to glomerular filtration rate (GFR), glomerular filtration rate (GFR) is currently the best comprehensive assessment of renal function indicators. Therefore, CysC has become a sensitive and specific indicator for evaluating early renal impairment. Now on its structure, measurement and evaluation of renal function and so on.