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目的探讨抗菌药物序贯疗法在改善小儿肺炎治疗效果中的作用。方法随机抽取于2016年1月至2017年1月时间段内笔者所在医院收治的肺炎患儿120例,以国际随机数字表法分为观察组和对照组,各60例患儿。对照组患儿给予常规静脉滴注阿莫西林/克拉维酸钾,观察组患儿给予阿莫西林/克拉维酸钾序贯治疗。结果观察组患儿的临床治疗有效率为96.67%,显著高于对照组的66.67%,P<0.05;观察组患儿的CRP和PCT水平,均显著低于对照组,P<0.05;观察组患儿的静脉炎、皮疹、恶心呕吐、食欲不振、腹泻等不良反应发生率为8.33%,显著低于对照组的28.33%,P<0.05。结论抗菌药物序贯疗法治疗小儿肺炎可显著改善患儿的CRP和PCT水平和临床治疗效果,并提高患儿的临床治疗安全性。
Objective To investigate the effect of sequential therapy with antimicrobial agents in improving the therapeutic effect of pneumonia in children. Methods A total of 120 children with pneumonia admitted to our hospital from January 2016 to January 2017 were randomly selected and divided into observation group and control group with 60 cases in each group by international random number table. Children in the control group were given routine intravenous infusion of amoxicillin / clavulanate potassium, while those in the observation group were given amoxicillin / clavulanate potassium sequential therapy. Results The effective rate of clinical treatment in observation group was 96.67%, which was significantly higher than that in control group (66.67%, P <0.05). The CRP and PCT levels in observation group were significantly lower than those in control group (P <0.05) Children with phlebitis, rash, nausea and vomiting, loss of appetite, diarrhea and other adverse reactions was 8.33%, significantly lower than the control group 28.33%, P <0.05. Conclusion Sequential antimicrobial treatment of children with pneumonia can significantly improve children’s CRP and PCT levels and clinical treatment, and improve the safety of clinical treatment in children.