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0引言her－abl融合基因编码的具有异常蛋白酪氨酸激酶活性的P210蛋白，是导致慢性粒细胞白血病（。hronicmveloidleukemia，CML）发生的主要原因．针对her－abl的核酶能有效抑制PZ10蛋白的合成，诱导CML细胞凋亡，是CML基因治疗的新思路．有关核酶及多核酶治疗CMI。的试验研究
1. Introduction P210 protein encoded by her-abl fusion gene with abnormal protein tyrosine kinase activity is the main cause of the development of chronic myeloid leukemia (CML). The ribozyme targeting her-abl can effectively inhibit the synthesis of PZ10 protein and induce apoptosis of CML cells. It is a new idea for CML gene therapy. About ribozymes and polynucleases treat CMI. Experimental study