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目的：探讨难治性复杂部分性癫 发作患者致 灶病理改变的特点。方法：对６例难治性复杂部分性癫 发作患者进行手术治疗。术前进行临床、神经电生理、神经心理及头颅ＣＴ检查，术中在脑皮层电图监测下作病侧前颞叶切除术，并作致 灶组织的病理学检查。结果：６例病人手术切除致 灶组织的病理学检查，有脑微血管的基底膜增厚与周细胞变性，均为非特异性改变。６例中术后发作减少＞５０％者１例，发作消失者５例，说明 灶定位正确，手术切除成功。结论：难治性复杂部分性发作的癫痫病人，其致 灶病理学检查多见周细胞变性及毛细血管基底膜增厚， 灶切除后可使发作消失或减少，若药物治疗无效应考虑手术治疗。
Objective: To investigate the characteristics of focal pathological changes in patients with refractory complex partial epilepsy. Methods: Six patients with refractory complex partial epilepsy were treated by surgery. Preoperative clinical, neurophysiological, neuropsychological and cranial CT examination, surgery in the cortex under the monitoring of electromyography before the disease temporal lobectomy, and as a result of focal tissue pathological examination. Results: The histopathological examination of 6 cases of patients with surgical resection resulted in non-specific changes in the thickening of basement membrane and pericytes of the cerebral microvessels. 6 cases of postoperative reduction in more than 50% in 1 case, 5 cases of seizures disappeared, indicating the correct positioning of the stove, the successful surgical resection. CONCLUSION: In patients with refractory and complicated partial epilepsy, the degenerative changes of pericytes and the thickening of capillary basement membrane due to focal pathology examination may disappear or decrease after focal resection. If the treatment is ineffective, surgical treatment should be considered .