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异腈是一个十分活泼的亲核成份。它与酸、胺、醛在Mannich反应条件下能生成具有肽骨架的缩合产物,称为四组份缩合。有二类四组份缩合,图1所表示的反应称为四组份缩合肤片断偶合,简写为4CC卜SC.图2所表示的反应称为四组份缩合立体选择性肤片断合成,简写为4CC一555。后者之不同于前者在于在产物分子中新生成了一个不对称的碳原子.
Isonitrile is a very active nucleophile. It with acids, amines, aldehydes under Mannich reaction conditions can produce condensation products with peptide backbone, known as the four-component condensation. There are two types of four-component condensation, the reaction shown in Figure 1 is called the four-component condensation of the cutaneous coupling, abbreviated as 4CC Bu SC Figure 2 shows the reaction is called the four-component condensation of stereoselective cutaneous synthesis, abbreviation For 4CC a 555. The latter differs from the former in that a new asymmetric carbon atom is formed in the product molecule.