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目的研究阿司匹林对人乳腺癌癌细胞株MCF-7增殖和凋亡的影响。方法 MTT法、FCM法、电镜等技术。结果 MTT法显示阿司匹林对人乳腺癌MCF-7细胞有较强的抑制作用;FCM法细胞的凋亡率随阿司匹林浓度的增大而增加;电镜可见典型的细胞凋亡形态学特征。结论阿司匹林能够显著抑制MCF-7细胞增殖及诱导凋亡。
Objective To study the effects of aspirin on proliferation and apoptosis of human breast cancer cell line MCF-7. Methods MTT method, FCM method, electron microscopy and other technologies. Results MTT assay showed that aspirin had a strong inhibitory effect on human breast cancer MCF-7 cells. The apoptosis rate of FCM increased with the increase of aspirin concentration. The morphological characteristics of apoptosis were typical under electron microscope. Conclusion Aspirin can significantly inhibit MCF-7 cell proliferation and induce apoptosis.