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宫颈癌是全球妇女中仅次于乳腺癌的恶性肿瘤,淋巴道转移是宫颈癌侵袭远处器官的主要途径之一,而宫颈癌的高病死率与淋巴结转移密切相关。肿瘤组织边缘微淋巴管是肿瘤细胞进入淋巴系统的主要门户,恶性肿瘤细胞主要是通过其周边组织的微淋巴管进入淋巴系统转移的。近年研究表明,VEGF及其家族成员不单在肿瘤血管生成,在微淋巴管生成中也是必不可少的诱导因子。本文综述对
Cervical cancer is the second most common malignant tumor among women in the world. Lymphatic metastasis is one of the major pathways of cervical cancer invading distant organs. However, the high mortality rate of cervical cancer is closely related to lymph node metastasis. Lymphatic vessels at the margin of tumor tissue are the main gateway for tumor cells to enter the lymphatic system. Malignant tumor cells mainly migrate through the lymphatic vessels of the surrounding tissues into the lymphatic system. In recent years, studies have shown that VEGF and its family members not only in tumor angiogenesis, lymphangiogenesis is also indispensable inducing factor. This article reviews