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目的:探讨血清EBV抗体检测联合~(99m)Tc-MIBI显像和MRI在诊断鼻咽癌放射治疗后复发中的价值。方法:60例鼻咽癌放射治疗后患者依据病理组织活检和临床随访复发21例,随访中均行血清EBV抗体检测、~(99m)Tc-MIBI显像显像和MRI检查。分别评价三者对鼻咽癌放疗后复发检出的灵敏度、特异性和准确度进行比较。结果:联合3种检查方法诊断鼻咽癌放疗后复发的灵敏度、特异性和准确率分别为100%、97.44%、和98.33%,其中灵敏度与单一检查方法比较差异无统计学意义;特异性与亲肿瘤显像比较差异无统计学意义,但与血清EBV抗体检测和MRI检查差异均具有统计学意义;准确率与单一检查方法差异均有统计学意义。结论:联合血清EBV抗体检测、~(99m)Tc-MIBI显像和MRI在诊断鼻咽癌放射治疗后复发中具有较高的价值,三种诊断方法有各自的优缺点,三者结合起来应用,可明显提高诊断鼻咽癌放射治疗后复发的准确性。
Objective: To investigate the value of serum EBV antibody combined with ~ (99m) Tc-MIBI imaging and MRI in the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy. Methods: Twenty-one patients with nasopharyngeal carcinoma after radiation therapy were retrospectively reviewed according to pathological biopsy and clinical follow-up. Serum EBV antibody, 99m Tc-MIBI imaging and MRI were used in the follow-up. Respectively, to evaluate the sensitivity, specificity and accuracy of the three detection of nasopharyngeal carcinoma recurrence after radiotherapy. Results: The sensitivity, specificity and accuracy of the three methods for the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy were 100%, 97.44%, and 98.33% respectively. There was no significant difference between the sensitivity and the single examination method. The specificity and specificity There was no significant difference between the two groups in tumor imaging, but there were significant differences between serum EBV antibody test and MRI examination. There was significant difference between accuracy and single examination method. Conclusion: The combination of serum EBV antibody, ~ (99m) Tc-MIBI imaging and MRI in the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy has a high value, the three diagnostic methods have their own advantages and disadvantages, the combination of the three applications , Can significantly improve the diagnosis of nasopharyngeal carcinoma recurrence after radiotherapy accuracy.