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近１０年来收治５４例肝硬化合并胃十二指肠溃疡患者，占同期住院肝硬化患者的５．８％（５４／９２６），其中４５例有上消化道出血史。本病发病机理为：①充血性胃十二指肠病变，微循环障碍和能量代谢异常，导致胃十二指肠粘膜的屏障功能和修复能力降低，易于溃疡形成。②幽门螺杆菌（ＨＰ）的感染，破坏了胃粘液及粘膜的屏障功能。③血液循环中液递物质增加，加重胃十二指肠充血、水肿和缺氧。④肝硬化肝功能失代偿，脾亢、凝血酶原时间延长，可造成溃疡出血。治疗原则：着重于止血，降低门静脉压力，保护肝功能和改善胃粘膜的微循环。
In the past 10 years, 54 patients with liver cirrhosis and gastroduodenal ulcer were admitted, accounting for 5.8% (54/926) of hospitalized cirrhosis patients in the same period. Among them, 45 patients had history of upper gastrointestinal bleeding. The pathogenesis of this disease: ① congestive gastroduodenal lesions, microcirculation and energy metabolism abnormalities, leading to gastroduodenal mucosal barrier function and repair ability to reduce, easy to ulcer formation. ② Helicobacter pylori (HP) infection, undermining the gastric mucus and mucosal barrier function. ③ blood circulation increase in fluid delivery substances, increase gastroduodenal congestion, edema and hypoxia. ④ Liver cirrhosis decompensated liver function, hypersplenism, prothrombin time can cause ulcer bleeding. Treatment principles: focus on hemostasis, reduce portal pressure, protect liver function and improve gastric mucosal microcirculation.