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介绍了作者近期利用苯甲酰亚胺化学结构构筑对生理环境pH值响应的药物输送体系的工作进展.亚胺(Schiff碱)作为动态共价键早已为人们所熟知,但其在pH敏感药物输送载体领域的应用并不多.苯甲酰亚胺由于苯环与碳氮双键共轭作用使其在生理pH值下的稳定性更好,同时具有在弱酸环境下(如固态肿瘤细胞外环境、内涵体环境等)的水解特性,适合作为pH响应性单元构筑药物控制释放载体,如聚合物胶束、纳米颗粒等.此外,利用Schiff碱反应随pH值改变的可逆性还可制备可注射凝胶等药物输送体系.
The recent progress of the drug delivery system that utilizes the chemical structure of benzimidazoles to construct a pH response to the physiological environment is introduced.Immine (Schiff base) has long been known as a dynamic covalent bond, but its application in pH-sensitive drugs There are not many applications in the field of transport carriers. Benzimides have better stability under physiological pH due to the conjugation of benzene ring and carbon-nitrogen double bond, and have the advantages of being more stable under physiological conditions such as solid tumor cells Environment, endosomal environment, etc.) suitable for use as a pH-responsive unit for the construction of drug controlled release carriers such as polymeric micelles, nanoparticles, etc. In addition, the Schiff base reaction can also be prepared using reversible pH changes Injection gel and other drug delivery system.