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目的探讨缬沙坦联合肾炎康复片治疗肾小球肾炎伴蛋白尿的临床疗效。方法选取重庆市铜梁区中医院2015年4月—2016年7月收治的肾小球肾炎伴蛋白尿患者104例,随机分为对照组和联合组,各52例。对照组患者单纯给予缬沙坦治疗,联合组患者在对照组基础上给予肾炎康复片治疗,两组患者均持续治疗12周。比较两组患者的临床疗效及治疗前后血压(舒张压、收缩压)、血脂(低密度脂蛋白胆固醇、总胆固醇)、24 h尿蛋白定量、血肌酐、肾小球滤过率、尿微量清蛋白/肌酐,并观察患者不良反应发生情况。结果联合组患者临床疗效优于对照组(P<0.05)。治疗前,两组患者舒张压、收缩压、低密度脂蛋白胆固醇、总胆固醇比较,差异无统计学意义(P>0.05);治疗后,联合组患者舒张压、收缩压、低密度脂蛋白胆固醇、总胆固醇低于对照组(P<0.05)。治疗前,两组患者24 h尿蛋白定量、血肌酐、肾小球滤过率、尿微量清蛋白/肌酐比较,差异无统计学意义(P>0.05);治疗后,联合组患者24 h尿蛋白定量、血肌酐、尿微量清蛋白/肌酐低于对照组,肾小球滤过率高于对照组(P<0.05)。两组患者不良反应发生率比较,差异无统计学意义(P>0.05)。结论采用缬沙坦联合肾炎康复片治疗肾小球肾炎伴蛋白尿的临床效果确切,可有效改善患者的血压、血脂水平,降低24 h尿蛋白定量、血肌酐,提升肾小球滤过率,安全有效。
Objective To investigate the clinical efficacy of valsartan combined with nephritis kangfu tablets in the treatment of glomerulonephritis with proteinuria. Methods 104 patients with glomerulonephritis with proteinuria admitted from April 2015 to July 2016 in Tongliang District Traditional Chinese Medicine Hospital of Chongqing were randomly divided into control group and combination group, with 52 cases in each group. Patients in the control group were treated with valsartan alone. Patients in the combined group were given nephritis rehabilitation tablets on the basis of the control group, and both groups were treated for 12 weeks. The clinical efficacy and the changes of blood pressure (diastolic blood pressure, systolic blood pressure), blood lipid (LDL cholesterol, total cholesterol), 24 h urinary protein, serum creatinine, glomerular filtration rate, Protein / creatinine, and observe the occurrence of adverse reactions in patients. Results The clinical efficacy of the combination group was better than that of the control group (P <0.05). Before treatment, there were no significant differences in diastolic blood pressure, systolic blood pressure, low-density lipoprotein cholesterol and total cholesterol between the two groups (P> 0.05). After treatment, diastolic blood pressure, systolic blood pressure, low density lipoprotein cholesterol , Total cholesterol lower than the control group (P <0.05). Before treatment, 24 h urinary protein, serum creatinine, glomerular filtration rate and urinary albumin / creatinine were not significantly different between the two groups (P> 0.05). After treatment, 24 h urine Protein quantification, serum creatinine, urinary albumin / creatinine were lower than those in the control group, and glomerular filtration rate was higher than that of the control group (P <0.05). Two groups of patients with adverse reactions, the difference was not statistically significant (P> 0.05). Conclusion The combination of valsartan and nephritis kangshen tablets in the treatment of glomerulonephritis with proteinuria clinical effect is exact, can effectively improve the patient’s blood pressure, blood lipid levels, reduce 24 h urinary protein, serum creatinine, glomerular filtration rate, Safe and effective.