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室内灰尘变应原(简称AHD)是日常生活中遇到的变应原之一,在支气管哮喘、过敏性鼻窦炎、异位性皮炎和一些类型的荨麻疹等许多过敏性疾病的病因和发病机理中起着重要作用。研究证明,给有过敏病史的人皮内注射室内灰尘提取物可产生速发型或迟发型反应。Tuft调查发现对AHD敏感性增高的异位性皮炎病人并不比哮喘病人少。作者亦发现异位性皮炎不仅可由皮内注射AHD而加重,亦可在吸入这些抗原时加重。已知在室内灰尘中包含许多无机物和有机物如:合成纤维、毛织品、丝绸、棉絮、羽毛、花粉、纸张、微生物(包括真菌芽孢和菌丝)、人排泄物(如痰)等。但是对AHD的化学本质至今还没有精确的报道。 Wodehouse用电泳等方法从AHD中分离出
Indoor dust allergens (AHDs), one of the allergens encountered in daily life, are responsible for the etiology and pathogenesis of many allergic diseases such as bronchial asthma, allergic rhinosinusitis, atopic dermatitis and some types of urticaria Mechanism plays an important role. Studies have shown that intradermal injection of indoor dust extract to persons with a history of allergies can produce either immediate or delayed reactions. Tuft survey found no increased risk of AHD patients with atopic dermatitis than asthma patients. The authors also found that atopic dermatitis was exacerbated not only by intradermal injection of AHD, but also by inhalation of these antigens. It is known that a large amount of inorganic substances and organic substances such as synthetic fibers, wool, silk, cotton wool, feathers, pollen, paper, microorganisms (including fungal spores and mycelium), human waste such as sputum and the like are contained in indoor dust. However, the chemical nature of AHD has not been reported accurately yet. Wodehouse electrophoresis and other methods from AHD isolated