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目的观察咪唑安定、异丙酚静脉麻醉在结肠镜诊治中的效果和安全性。方法镇静组、对照组各40例,观察两组检查前、中、后血压、心率和氧饱和度变化,比较结肠镜操作效果及不良反应。结果镇静组40例患者均4级睡眠状态下完成操作,到达回盲部成功率为100%,到达回盲部时间为8.0±2.7分钟,对照组达回盲部时间为12.6±4.0分(P<0.05),镇静组25例患者无需变动体位即到达回盲部,而对照组仅2例(P<0.05)。镇静组检查前、中、后血压、心率、氧饱和度比较均无明显变化(P>0.05);对照组均有不同程度的疼痛,评分>6分的15例。检查中与检查前后比较,血压升高、心率变快(P<0.05),氧饱和度比较无差异(P>0.05)。结论咪唑安定和异丙酚联合静脉麻醉下的结肠镜诊治,安全有效,操作便利,时间缩短,不良反应低。
Objective To observe the efficacy and safety of midazolam and propofol intravenous anesthesia in the diagnosis and treatment of colonoscopy. Methods 40 cases in each group were treated with sedation and control. The changes of blood pressure, heart rate and oxygen saturation were observed before, during and after the operation. The operation effect and adverse reactions of the colonoscopy were compared. Results All the 40 patients in the sedation group completed the operation in Grade 4 sleep state. The success rate of reaching the ileocecal part was 100%, the time to reach the ileocecal part was 8.0 ± 2.7 minutes, and the time to the ileocecal part of the control group was 12.6 ± 4.0 (P <0.05). There were 25 patients in the sedation group who reached the ileocecal region without changing position, while only 2 patients in the control group (P <0.05). There was no significant difference in blood pressure, heart rate and oxygen saturation between the sedation group before, during and after the examinations (P> 0.05). The control group had 15 cases with different degrees of pain and score> 6 points. Compared with before and after the examination, blood pressure, heart rate faster (P <0.05), oxygen saturation no difference (P> 0.05). Conclusions Midazolam and propofol combined with intravenous anesthesia in the diagnosis and treatment of colonoscopy, safe and effective, easy to operate, shorten the time, adverse reactions.