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目的观察金双歧联合思密达治疗婴幼儿腹泻的临床疗效及不良反应。方法本组146例急性腹泻患儿按前瞻性、随机化原则分为观察组和对照组各73例,对照组给予调整饮食、补液、对症处理等基础治疗,观察组在此基础上加用金双歧、思密达口服,疗程3d。观察临床疗效及不良反应。结果观察组显效62例,显效率达84.93%,有效9例,无效2例,总有效率为97.26%;对照组显效35例,显效率47.95%,有效25例,无效13例,总有效率为82.19%。观察组显效率明显高于对照组,差异有显著统计学意义(P<0.01);两组总有效率比较差异亦有统计学意义(P<0.05)。两组治疗期间均无明显不良反应发生。结论金双歧、思密达联用有相互协同作用,有利于恢复肠道微生态平衡及病原微生物的排出,恢复肠道内环境稳定,临床疗效确切,且不良反应少,值得临床推广应用。
Objective To observe the clinical efficacy and adverse reactions of Jinshuangqi combined with Smecta in the treatment of infantile diarrhea. Methods A total of 146 cases of acute diarrhea in this group were divided into observation group and control group according to the principle of randomization. The control group was given basic treatment such as diet, rehydration and symptomatic treatment. On the basis of this observation group, , Smectite oral, treatment 3d. To observe the clinical efficacy and adverse reactions. Results The observation group was significantly improved in 62 cases, markedly effective rate was 84.93%, effective in 9 cases, ineffective in 2 cases, the total effective rate was 97.26%; control group markedly effective in 35 cases, markedly effective rate of 47.95%, effective in 25 cases, ineffective in 13 cases, total effective rate 82.19%. The effective rate of the observation group was significantly higher than that of the control group, the difference was statistically significant (P <0.01). The total effective rate was also significantly different between the two groups (P <0.05). No significant adverse reactions occurred during treatment in both groups. Conclusions Jinshiku and Smecta combined play a synergistic role in restoring intestinal microflora and excretion of pathogenic microorganisms and restoring stable intestinal environment. The clinical curative effect is definite and the adverse reactions are few, which is worthy of clinical application.