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细胞内钙离子(Ca2+)稳态的维持对生命活动是至关重要的,细胞变性坏死可能与胞内Ca2+超载有关。细胞内Ca2+水平的调节通过以下途径实现:钙通道、Na+-Ca2+交换、钙泵以及细胞内部的Ca2+摄取与释放(线粒体和肌浆网等)。近年来许多研究已表明,耳蜗毛细胞和螺旋神经节细胞等细胞膜上
The maintenance of intracellular calcium ion (Ca2 +) homeostasis is crucial to life activity, and cell degeneration and necrosis may be related to intracellular Ca2 + overload. Regulation of intracellular Ca2 + levels is achieved through calcium channels, Na + -Ca2 + exchange, calcium pumps, and intracellular Ca2 + uptake and release (mitochondria and sarcoplasmic reticulum, etc.). In recent years, many studies have shown that cochlear hair cells and spiral ganglion cells and other cell membranes