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目的：研究p16和C－myc在喉鳞状细胞癌中的表达意义。方法：应从p16和C－myc单克隆抗体，通过免疫组织化学法检测6例正常喉粘膜和47例喉鳞癌中p16和C－myc的表达。结果：6例正常喉粘膜组织中未发现p16和C－myc蛋白阳性表达，47例喉鳞癌中p16和C－myc阳性表达率分别为48．9％（23／47）和57.4％（27／47），与性别、年龄和肿瘤发生的部位无相关性（P＞0．05），与临床分期和病理分级相关（P＜0．05）；C－myc还与颈淋巴结转移相关（P＜0．05）。结论：p16和C-myc蛋白阳性表达在喉鳞癌的发生和发展中起重要作用，可作为评价喉鳞癌预后的新指标。
Objective: To study the expression of p16 and C-myc in laryngeal squamous cell carcinoma. Methods: The expression of p16 and C-myc in six cases of normal laryngeal squamous cell carcinoma and 47 cases of laryngeal squamous cell carcinoma were detected by immunohistochemistry from p16 and C-myc monoclonal antibodies. RESULTS: No positive expression of p16 and C-myc was found in 6 cases of normal laryngeal mucosa. The positive rates of p16 and C-myc in 47 cases of laryngeal squamous cell carcinoma were 48.9% (23/47) and 57.4% (27/27), respectively / 47). There was no correlation with gender, age and location of tumor (P> 0.05), and was correlated with clinical stage and pathological grade (P <0.05). C-myc also correlated with cervical lymph node metastasis <0.05). Conclusion: The positive expression of p16 and C-myc protein plays an important role in the occurrence and development of laryngeal squamous cell carcinoma and may be used as a new index to evaluate the prognosis of laryngeal squamous cell carcinoma.