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目的探讨老年男性代谢综合征相关指标与血清前列腺特异性抗原(prostate-specific antigen,PSA)水平的关系。方法选择2005年4月至2009年1月在我科就诊的375例老年男性,测量身高、体质量,24小时动态血压监测,计算体质量指数(body mass index,BMI),平均动脉压(mean arterial blood pressure,MAP),检测血PSA、胆固醇(TC)、甘油三酯(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、空腹血糖(FBG)、C反应蛋白(CRP)、尿酸(UA),分析血PSA与代谢综合征各项指标的相关性。结果血PSA与BMI呈负相关(rs=-0.113,P<0.05),PSA与年龄(rs=0.109,P<0.05)、甘油三酯(rs=0.111,P<0.05)、空腹血糖(rs=0.166,P<0.01)、C反应蛋白(rs=0.115,P<0.05)呈正相关。结论老年男性血PSA水平与BMI、年龄、甘油三酯、空腹血糖、C反应蛋白存在相关性,代谢综合征的相关指标可影响血PSA水平,从而影响前列腺疾病的发生。
Objective To investigate the relationship between the metabolic syndrome-related indicators and the serum level of prostate-specific antigen (PSA) in elderly men. Methods A total of 375 elderly men in our department from April 2005 to January 2009 were enrolled in the study. Height, body weight, 24-hour ambulatory blood pressure monitoring, body mass index (BMI), mean arterial pressure (mean arterial blood pressure (MAP)), blood PSA, cholesterol (TC), triglyceride (TG), high density lipoprotein cholesterol (HDL-C), low density lipoprotein cholesterol (LDL-C), fasting blood glucose (FBG) , CRP, UA, blood PSA and the metabolic syndrome. Results There was a negative correlation between PSA and BMI (rs = -0.113, P <0.05), PSA and age (rs = 0.109, 0.166, P <0.01), C-reactive protein (rs = 0.115, P <0.05). Conclusion There is a correlation between serum PSA level and BMI, age, triglyceride, fasting blood glucose and C-reactive protein in elderly men. The related indicators of metabolic syndrome may affect the level of serum PSA and thus the incidence of prostate disease.