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目的:通过对慢性肾功能衰竭患者临床症状、尿蛋白及血肌酐水平变化的研究,评价益肾健脾汤对慢性肾功能衰竭的治疗作用.方法:选取2012年10月～2016年6月来我院就诊的慢性肾功能衰竭患者为研究对象,评估后选出300例患者进行试验.试验前,使用随即发生器将所有受试者随机分成两组,试验组(n=150)和对照组(n=150).对照组患者接受基础对症治疗,试验组患者在对照组的基础上给予口服益肾健脾汤治疗.通过对比两组患者的临床症状特征变化和尿蛋白、血肌酐水平变化,评价益肾健脾汤对慢性肾功能衰竭的治疗效果.结果①总体疗效:经过治疗,统计得到试验组的治疗总有效率为86.67％,对照组患者的总有效率为56.67％,两组之间的差异具有统计学意义(P＜0.05).②症状积分:经过治疗,比较两组慢性肾功能衰竭患者的症状积分,试验组与对照组之间的差异显著,具有统计学意义(P＜0.05).③实验室指标:与治疗前相比,两组患者蛋白尿、血清肌酐水平均有明显降低,差异具有统计学意义(P＜0.05);治疗后两组患者蛋白尿、血肌酐水平比较,差异具有统计学意义(P＜0.05).结论:益肾健脾汤能够有效改善慢性肾功能衰竭患者的临床症状,降低患者蛋白尿及血清肌酐水平,对于慢性肾功能衰竭患者的治疗具有确切疗效.“,”Objective:Based on the study of the changes of clinical symptoms,urinary protein and serum creatinine to estimate the therapeutic effect of Yishen Jianpi Decoction on CRF.Methods:The main research subjects were selected from the patients with chronic renal failure in our hospital from October 2012 to June 2016.After the evaluation,300 patients were selected for the study.Before the experiment,all the subjects were randomly divided into two groups,the test group (n=150) and the controlled group (n =150).Patients in the controlled group received basic treatment,while the patients in the experimental group were given the Yishen Jianpi Decoction.By comparing the two groups of patients with the symptoms ofchange and protein urine,serum creatinine level changes to evaluate the therapeutic effect of Yishen Jianpi Decoction on chronic renal failure.Resuits:① Overall efficacy:after treatment,the total effective rate of the treatment group was 86.67％,the total effective rate of the controlled group was 56.67％,the difference between the two groups was statistically significant (P ＜ 0.05).② Symptom score:after treatment,the symptom scores of the two groups of patients with chronic renal failure were compared,the difference between the experimental group and the controlled group was statistically significant (P ＜ 0.05).③ Laboratory index:compared with before treatment,two groups of patients with proteinuria,serum creatinine levels were significantly decreased,the difference was statistically significant (P ＜ 0.05);compared two groups of patients with proteinuria and serum creatinine level after treatment,the difference was statistically significant (P ＜ 0.05).Conclusion:Yishen Jianpi Decoction can effectively improve the clinical symptoms of patients with chronic renal failure,reduce proteinuria and serum creatinine levels,for the treatment of patients with chronic renal failure has a definite effect.