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目前认为细胞介导的自身免疫反应在慢活肝的发病原理中起着作用。这些病人对肝特异的细胞膜脂蛋白(LSP)呈变态反应,其淋巴细胞对同种肝细胞显示细胞毒作用,但可被LSP所阻断,提示LSP为主要作用的靶抗原。本文报告66例慢活肝病人淋巴细胞对家兔肝细胞的毒性作用,并与疗效、临床和组织学改变的关系作一比较。用微量法测定淋巴细胞对家兔离体培养肝细胞的毒性。35例正常对照组的细胞毒性低于32%(均值±2 S.D),对120例同一标本作2次测定,其中56例(47%)的误差少于10%;96例(80%)的误差少于
It is currently thought that cell-mediated autoimmune reactions play a role in the pathogenesis of slow-living liver. These patients are allergic to liver-specific membrane lipoprotein (LSP) and their lymphocytes show cytotoxic effects on allogeneic hepatocytes but are blocked by LSP, suggesting LSP as the primary target antigen. In this paper, we report the toxic effects of lymphocytes from 66 patients with chronic liver disease on hepatocytes in rabbits and compare their effects with clinicopathological and histological changes. Toxicity of lymphocytes to rabbit hepatocytes cultured in vitro by microtiter method. Cytotoxicity was less than 32% (mean ± 2 SD) in 35 normal controls and twice in 120 identical specimens, with 56 (47%) with less than 10% error; 96 (80%) with Less than error