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目的 探讨人类巨细胞病毒 (HCMV)感染与冠心病的关系。方法 采用间接ELISA法检测其外周血巨细胞病毒抗体 ,同时应用免疫透射比浊法测定其C反应蛋白的水平。结果 冠心病组 6 0例 ,外周血巨细胞病毒抗体IgG阳性 2 6例 (4 3 3% ) ,健康对照组 6 0例中阳性 10例 (16 6 % ) ,两组比较差异有显著意义 (P <0 0 5 )。HCMV抗体阳性者 2 6例同时检测外周血CRP水平大于正常者 2 0例 (76 9% ) ,正常对照组2 6例CRP水平大于正常者 3例 (11 5 % ) ,两组比较差异有显著意义 (P <0 0 1)。结论 巨细胞病毒感染与冠心病之间关系密切。
Objective To investigate the relationship between human cytomegalovirus (HCMV) infection and coronary heart disease. Methods Antibody of cytomegalovirus in peripheral blood was detected by indirect ELISA, and the level of C-reactive protein was measured by immunoturbidimetry. Results Sixty-three patients (36.3%) had positive IgG antibodies against peripheral blood cytomegalovirus in 60 CHD patients and 10 (16.6%) positive patients in 60 healthy controls. There was significant difference between the two groups P <0 0 5). HCMV antibody positive 26 cases of simultaneous detection of peripheral blood CRP levels were higher than the normal 20 cases (76.9%), 26 cases of normal control group CRP levels were higher than normal in 3 cases (11 5%), the difference between the two groups was significant Significance (P <0 0 1). Conclusion Cytomegalovirus infection is closely related to coronary heart disease.