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目的探讨唐氏综合症与部分环境因素的关系。方法将就诊儿童分为唐氏综合症组和对照组,对唐氏综合症组患儿和父母进行染色体核型分析。调查分析母亲的环境因素。结果 100例患儿中三体型、易位型、嵌合型分别占89%、10%、1%。出生时母亲年龄在30岁以下者55例占55%。母亲接触化学物质在两组间的差异有统计学意义(χ2=26.61,P<0.01)。结论母亲生育年龄不是唐氏综合症患儿出生的主要因素,环境因素与唐氏综合症的发生有密切关系。
Objective To explore the relationship between Down Syndrome and some environmental factors. Methods The children were divided into Down Syndrome group and control group, and the karyotypes of children and parents in Down Syndrome group were analyzed. Investigate and analyze the mother’s environmental factors. Results 100 cases of children with trisomy, translocation, chimeric accounted for 89%, 10%, 1%. 55 were 55% of mothers under the age of 30 at birth. There was a statistically significant difference between the two groups in exposure of mother to chemical substances (χ2 = 26.61, P <0.01). Conclusion The mother’s reproductive age is not the main factor of birth in children with Down’s syndrome. The environmental factors are closely related to the occurrence of Down’s syndrome.