论文部分内容阅读
目的通过筛选增强青黛亲水性的改性剂来研究改性剂与青黛作用方式,并优选出最佳改性工艺,制备适宜汤剂给药的新型饮片,满足临床用药需求。方法以接触角为亲水改性效果评价指标,通过筛选出不同醇类试剂中最优的改性剂,再经过不同的干燥温度对改性青黛进行热稳定性考察,结合不同醇类试剂、靛蓝、靛玉红的微观结构来初步探讨改性剂与青黛改性作用机制以及改性效果的热稳定性。通过单因素试验考察探讨接触角与改善青黛亲水性的关系,并采用均匀设计初步确定最佳工艺。结果不同醇类试剂相较于普通青黛都有改性效果,改性过程中醇分子的-CH3和-OH贡献不同,一元醇碳链越长改性效果越好,多元醇-OH越多改性效果越好,但从试剂的适用性及安全性考虑最佳改性剂为乙醇,最优改性工艺:改性剂用量为19%的乙醇、研磨23 min。结论醇类能有效改善青黛的润湿问题,使用乙醇作为改性剂可行性好,改性工艺稳定可靠,可以成功制备出青黛饮片。
OBJECTIVE To study the mode of action of modifier and indigo by screening modifiers that enhance the hydrophilicity of indigo, and optimize the modification process to prepare a new type of decoction suitable for decoction to meet the needs of clinical medication. Methods The contact angle was used to evaluate the effect of hydrophilic modification. By screening out the best modifiers of different alcoholic reagents, the thermal stability of the modified indigo was studied by different drying temperatures. Combined with different alcoholic reagents, Indigo, indirubin microstructure to preliminary study modifier and indigo modified mechanism and the thermal stability of the modified effect. The relationship between the contact angle and the hydrophilicity of Indigo camellia was discussed through single factor test, and the uniform design was used to determine the optimal process. Results Compared with ordinary indigo, different alcoholic reagents had modification effect, and the contribution of -CH3 and -OH to alcohol molecules in the modification process was different. The longer the mono-alcohol carbon chain, the better the modification effect and the more polyol-OH The better the sexual effect, but the best modifier is ethanol from the applicability and safety of the reagent. The optimum modification process is that the amount of modifier is 19% ethanol and grinding is carried out for 23 min. Conclusions Alcohols can effectively improve the wetness of indigo. The feasibility of using ethanol as modifier is good. The modification process is stable and reliable, and the indigo can be successfully prepared.