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目的了解急性心肌梗死中是否存在缺血预适应现象并评价缺血预适应对急性心肌梗死患者预后的影响。方法通过对我院1996年以来共260例急性心肌梗死病历进行回顾性研究,依发病前24～48h内有无心绞痛发作分为缺血预适应组(IP组)和无缺血预适应组(NIP组)。观察两组间ST段抬高程度、心肌酶峰值及休克、心力衰竭、死亡发生率的差异。结果IP组ST段抬高的程度、心肌酶峰值、休克、心力衰竭及死亡的发生机会均低于NIP组(P<0.05)。结论IP可明显改善急性心肌梗死患者的预后。
Objective To investigate whether ischemic preconditioning exists in acute myocardial infarction (AMI) and evaluate the effect of ischemic preconditioning on the prognosis of patients with acute myocardial infarction. Methods A total of 260 cases of acute myocardial infarction in our hospital since 1996 were retrospectively studied. According to the occurrence of angina pectoris within 24 ~ 48 hours before onset, the patients were divided into ischemic preconditioning group (IP group) and non-ischemic preconditioning group NIP group). The difference of ST segment elevation, myocardial enzyme peak, shock, heart failure and death rate between the two groups was observed. Results The degree of ST segment elevation, peak myocardial enzymes, shock, heart failure and the chances of death in IP group were all lower than those in NIP group (P <0.05). Conclusion IP can significantly improve the prognosis of patients with acute myocardial infarction.