Metabolic reprogramming in triple-negative breast cancer

• 作 者: Zhanyu Wang Qianjin Jiang Chenfang Dong
• 机 构: Department of Surgical Oncology(Breast Center)of The Second Affiliated Hospital, Zhejiang University
• 出 处: 癌症生物学与医学（英文版）
• 发表日期: 2020年1期
• 关键词: Metabolic reprogramming triple-negative breast cancer aerobic glycolysis Warburg

Since triple-negative breast cancer (TNBC) was first defined over a decade ago,increasing studies have focused on its genetic and molecular characteristics.Patients diagnosed with TNBC,compared to those diagnosed with other breast cancer subtypes,have relatively poor outcomes due to high tumor aggressiveness and lack of targeted treatment.Metabolic reprogramming,an emerging hallmark of cancer,is hijacked by TNBC to fulfill bioenergetic and biosynthetic demands;maintain the redox balance;and further promote oncogenic signaling,cell proliferation,and metastasis.Understanding the mechanisms of metabolic remodeling may guide the design of metabolic strategies for the effective intervention of TNBC.Here,we review the metabolic reprogramming of glycolysis,oxidative phosphorylation,amino acid metabolism,lipid metabolism,and other branched pathways in TNBC and explore opportunities for new biomarkers,imaging modalities,and metabolically targeted therapies.