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目的 探讨大肠癌组织DNA含量的8个参数同生物学特性的相关性。方法 应用计算机图像分析DNA定量的方法(ICM)对65例大肠癌标本进行DNA定量分析。结果 异倍体检出率同大肠癌淋巴结转移与Dukes分期具有正相关性;S相细胞比率(SPF)与G_2/M相细胞比率(G_2/MPF)同大肠癌组织分化,淋巴结转移,Dukes分期均具有正相关性。结论 异倍体肿瘤,SPF,G_2/MPF三者联合检测对大肠癌的诊断与治疗具有重要价值。
Objective To explore the correlation between eight parameters of DNA content in colorectal cancer tissue and biological characteristics. Methods DNA quantitative analysis of 65 colorectal cancer specimens was performed using computer image analysis (ICM). Results The heteroploid detection rate was positively correlated with lymph node metastasis and Dukes stage of colorectal cancer. S phase cell ratio (SPF) and G 2 /M phase ratio (G 2 /MPF) were the same as colorectal cancer tissue differentiation, lymph node metastasis, and Dukes stage. Have a positive correlation. Conclusion The combined detection of aneuploid tumors, SPF and G2/MPF has important value in the diagnosis and treatment of colorectal cancer.