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Ghrelin是一个由 2 8个氨基酸组成的多肽 ,3位丝氨酸上有酰化基团。它是第一个被发现的生长激素促分泌剂受体 (GHS R)的内源性配体。Ghrelin主要由胃分泌 ,下丘脑、肾脏、胎盘均有分泌。GHS R分布在多种组织 ,而且有不同的亚型 ,它有很强的促生长激素 (GH)释放的作用 ,可使循环中GH迅速、显著而持久地增加 ,甚至比生长激素释放激素的作用还强。Ghrelin是促进食欲的脑肠肽 ,参与下丘脑、垂体和胃肠道共同对能量平衡的调节
Ghrelin is a polypeptide of 2 to 8 amino acids with an acylated group on serine 3. It is the first endogenous ligand for the discovered growth hormone secretagogue receptor (GHS R). Ghrelin secretion mainly by the stomach, hypothalamus, kidney, placenta are secreted. GHS R distributes in a variety of tissues and has different subtypes. It has a strong release of somatotropin (GH) and can rapidly, significantly and persistently increase GH in circulation, even higher than that of ghrelin The role is also strong. Ghrelin is an appetite-inducing ghrelin involved in the regulation of energy balance by the hypothalamus, pituitary and gastrointestinal tract