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Preparation and blood compatibility of different shape polyvinyl alcohol(PVA) membrane were investigated. Firstly, the tabular and tubular[polytetrafluoroethylene(PTFE) capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol(mPEG) was grafted onto the surface of the PVA membranes. The effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could availably repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.
Firstly, the tabular and tubular [polytetrafluoroethylene (PTFE) capillary as supporter] PVA membranes were prepared; then, methoxy polyethylene glycol (mPEG) was grafted onto the surface of the effects of the shape, structure and properties of the membrane surface on blood compatibility were studied in detail. The experiment results show that mPEG modified PVA membranes, especially mPEG modified tubular membrane, could a repel the adhesion of the platelets. In addition, the anticoagulant mechanism of mPEG with a steric repulsion effectiveness was confirmed further via different grafting methods.