A facile electrochemical method for the synthesis of new sulfonamide derivatives of potential biolog

• 作 者: Davood Nematollahi Saied Saeed Hosseiny Davarani Pari Mirahmadpour Fahimeh Varmaghani
• 机 构: Faculty of Chemistry,Bu-Ali Sina University,Department of Chemistry,Faculty of Science,University of
• 出 处: Chinese Chemical Letters
• 发表日期: 2014年04期
• 关键词: facile friendly electrolysis manner pharmaceutical anode cathodic anodic antibac

The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2.3-dihydrophthalazine-l,4-dione(1) in the presence of arylsulfinic acids(2a and 2b) as nucleophiles.The results show that,the electrogenerated phthalazine-l,4-dione(lox)participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives.This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.

The electrochemical synthesis of some new sulfonamide derivatives was carried out via the electrochemical oxidation of 2.3-dihydrophthalazine-l, 4-dione (1) in the presence of arylsulfinic acids (2a and 2b) as nucleophiles.The results show that, the electrogenerated phthalazine -l, 4-dione (lox) participates in a Michael type addition reaction with 2a or 2b and via an EC mechanism to produce the corresponding sulfonamide derivatives. This method provides a one-pot procedure for the synthesis of new sulfonamide derivatives of potential biological significance in good yields without using toxic reagents at a carbon electrode in an environmentally friendly manner.