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近年,α_1-微球蛋白(α_1-MG)因作为表示肾功能的特异指标而受到注目。它是分子量为33000的糖蛋白,与几乎分布于全身各组织的β_2-MG不同,主要在淋巴细胞和肝脏中生成,存在于血清、尿、脊髓液中。它易通过肾小球,在肾小管几乎全部被吸收,或被异化而排出。因此,临床上可望用它作为判定肾功能障碍程度的一种血浆蛋白。现在,我们测定血清和尿中的α_1-MG与β_2-MG,血清Cr、24小时CCr、尿中N-乙酰-β氨基葡萄糖酶(NAG)并加以比较、探讨α_1-MG对肾功能评价的实用性。对象以市立室蓝综合医院泌尿科从1985年11月到1986年10月检查的28例非肿瘤性疾病为对象,包括:前列腺肥大8例,尿路结石6例,慢性肾功能不全3例,尿道狭窄3例,膀胱尿管逆流2例,肾结核2例,急性前列腺炎、马蹄肾、囊胞肾、肾小球肾炎各1例。
In recent years, α 1-microglobulin (α 1-MG) has been attracting attention as a specific indicator of renal function. It is a glycoprotein with a molecular weight of 33,000, which is different from β_2-MG which is almost distributed in various tissues of the body. It is mainly produced in lymphocytes and liver and exists in serum, urine and spinal fluid. It is easily passed through the glomerulus, is almost absorbed in the tubules, or is excreted. Therefore, it is clinically expected to use it as a plasma protein to determine the degree of renal dysfunction. Now, we measured α_1-MG and β_2-MG in serum and urine, serum Cr, CCr 24 hours, urine N-acetyl-β-glucosaminidase (NAG) Practicality. The subjects were selected from 28 non-neoplastic diseases examined in Urology of Municipal Blue General Hospital from November 1985 to October 1986, including 8 cases of benign prostatic hyperplasia, 6 cases of urinary tract stones, 3 cases of chronic renal insufficiency, 3 cases of urethral stricture, 2 cases of bladder urinary reflux, 2 cases of renal tuberculosis, acute prostatitis, horseshoe kidney, cystic kidney, glomerulonephritis in 1 case.