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目的:探讨中毒剂量苯妥英钠(DPH-Na)给药后唾液与血浆、组织间浓度的相关性。方法:大鼠静注中毒剂量DPH-Na后,采集血液、组织及唾液样品,HPLC法测定其中DPH-Na浓度,线性回归法计算唾液与血浆及组织间浓度的相关关系。结果:大鼠DPH-Na中毒后在唾液中有少量排泄,唾液与血液及脑组织中DPH-Na浓度间存在良好相关关系,与唾液浓度/其它组织浓度比(S/T比)之间均存在显著相关性。结论:DPH-Na中毒后,可以通过测定唾液中浓度了解其在血液及组织中分布情况。
Objective: To investigate the correlation between saliva, plasma and interstitial concentration after poisoning dose of phenytoin sodium (DPH-Na). Methods: After intravenous injection of DPH-Na, blood, tissues and saliva samples were collected from rats. The concentration of DPH-Na was determined by HPLC. The correlation between saliva and plasma and interstitial concentration was calculated by linear regression. Results: After excretion of DPH-Na in rats, there was a small amount of excretion in saliva. There was a good correlation between saliva and DPH-Na concentration in blood and brain tissue, and saliva concentration / other tissue concentration ratio (S / T ratio) There is a significant correlation. Conclusion: After DPH-Na poisoning, the distribution in the blood and tissues can be determined by measuring the concentration in saliva.