S14G-humanin restored cellular homeostasis disturbed by amyloid-beta protein

• 作 者: Xue Li Wencong Zhao Hongqi Yan
• 机 构: DepartmentofNeurology,DepartmentofNeurology,DepartmentofPharmacology
• 出 处: 中国神经再生研究：英文版
• 发表日期: 2013年27期
• 关键词: Β-淀粉样蛋白 神经保护作用 老年痴呆症 稳态 细胞 干扰 海马神经元 分子机制 neural regeneration Alzheimer＇s disease
• 基金项目: This study was supported by grants from Henan Medical Technologies R＆D Program in China, No.200703023,201203130 and Henan Key Science and Technology Project in China, No.112102310684

Humanin is a potential therapeutic agent for Alzheimer’s disease,and its derivative,S14G-humanin,is 1 000-fold stronger in its neuroprotective effect against Alzheimer’s disease-relevant insults.Although effective,the detailed molecular mechanism through