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为探讨子宫腺瘤样瘤的病理学特点及组织来源和发病机制,对子宫腺瘤样瘤22例观察其临床病理特征,应用免疫组化和组织化学方法进行染色观察。结果表明,22例中8例见瘤组织与浆膜面间皮相移行,14例见瘤组织与周围平滑肌组织有连续;免疫组化显示瘤细胞波纹蛋白、细胞角蛋白、间皮细胞抗原阳性表达;表皮膜抗原、癌胚抗原、血管相关因子和HHF35阴性表达;组织化学染色显示粘液染色有阳性表达,嗜银染色见瘤细胞周围嗜银纤维少,糖原染色阴性。结论:子宫腺瘤样瘤为良性病变,起源于间皮组织,为浆膜间皮细胞异位浆膜下肌间所致。组织化学、免疫组化结果可作为诊断及鉴别诊断的重要参考依据。
In order to explore the pathological features of uterine adenoma-like tumor and its origin and pathogenesis, the clinical and pathological features of uterine adenoma-like tumor were observed in 22 cases. The immunohistochemistry and histochemical staining were used to observe the pathological features. The results showed that in 22 of 22 cases, the mesothelioma was found in 8 cases, and in 14 cases, the tumor tissues were continuous with the surrounding smooth muscle. Immunohistochemistry showed the positive expression of vimentin, cytokeratin and mesothelial cell antigen ; Epidermal membrane antigens, carcinoembryonic antigen, vascular related factors and HHF35 negative expression; histochemical staining showed positive expression of mucus staining, silver staining of argyrophilic cells found around the tumor cells less silver, glycogen staining negative. Conclusion: The uterine adenomatoid tumor is a benign lesion, originated from the mesothelial tissue, which is caused by the heterotopic subserosal muscle of serosal mesothelial cells. Histochemistry, immunohistochemistry results can be used as an important reference for diagnosis and differential diagnosis.