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作者采用放射免疫分析法，测定了６３例恶性血液病患者（其中３３例伴多脏器功能衰竭，３０例无多脏器功能衰竭）及３０例正常人的血浆内皮素水平。结果表明：恶性血液病伴多脏器功能衰竭者血浆内皮素水平明显高于无多脏器功能衰竭者和正常人。恶性血液病血浆内皮素水平随受累脏器的增多而增高，死亡率也随之升高。提示：恶性血液病发生多脏器功能衰竭伴有明显的血管收缩和微循环紊乱。动态监测血浆内皮素水平可作为对恶性血液病疗效判断及预后估计的一个指标。
The authors used radioimmunoassay to determine plasma endothelin levels in 63 patients with hematologic malignancies (33 with multiple organ failure, 30 without multiple organ failure) and 30 normal subjects. The results showed that the level of plasma endothelin in patients with hematologic malignancies complicated with multiple organ failure was significantly higher than those without multiple organ failure and normal. The level of plasma endothelin in patients with hematologic malignancies increases with the increase of organs involved, and the mortality rate also increases. Tip: Malignant blood disease occurred multiple organ failure accompanied by significant vasoconstriction and microcirculation disorder. Dynamic monitoring of plasma endothelin levels can be used as an indicator of efficacy and prognosis of hematologic malignancies.