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目的 研究盐酸戊乙奎醚对重度有机磷并发接触性皮炎患者的治疗机制。方法 40例重度有机磷并发接触性皮炎患者随机分为盐酸戊乙奎醚治疗组及阿托品治疗组;采集入院12、48、72h接触性皮炎患者皮损渗出物,用ELISA法检测高迁移率族蛋白B1(HMGB1)、肿瘤坏死因子(TNF)-α的浓度。结果 盐酸戊乙奎醚治疗组皮损渗出物中HMGB1、TNF-α浓度低于阿托品治疗组,二者差异有显著统计学意义(P<0.01)。结论 盐酸戊乙奎醚通过抑制接触性皮炎皮损处炎症细胞中HMGB1、TNF-α的表达,减轻有机磷中毒的皮肤炎症反应。
Objective To study the therapeutic mechanism of penehyclidine hydrochloride in patients with severe organophosphorus complicated with contact dermatitis. Methods Forty patients with severe organophosphorus concurrent contact dermatitis were randomly divided into penehyclidine hydrochloride group and atropine group. Exfoliative skin lesions were collected from patients with contact dermatitis at admission for 12, 48, and 72h. High migration rate Family protein B1 (HMGB1), tumor necrosis factor (TNF) -alpha. Results The concentration of HMGB1 and TNF-α in the skin lesions of penehyclidine hydrochloride group was lower than that of atropine group (P <0.01). Conclusion Penehyclidine hydrochloride can reduce the inflammatory reaction of skin due to organophosphorus poisoning by inhibiting the expression of HMGB1 and TNF-α in inflammatory cells of contact dermatitis lesions.