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1971年Shell氏等设计出利用急性心肌梗塞(AMI)后系列血清磷酸肌酸激酶(CPK)活力改变计算梗塞范围的经验数学公式,并于次年应用于临床。当时已知从坏死心肌释放的CPK并非全部进入血循环,进
In 1971, Shell et al. Designed an empirical mathematical formula for calculating the range of infarction by using the change of serum creatine phosphokinase (CPK) after acute myocardial infarction (AMI), and in clinical application in the following year. At that time, it was known that CPK released from necrotic myocardium did not all enter the blood circulation