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目的比较妊娠高血压综合征(PIH)女性与非PIH女性远期非酒精性脂肪肝(NAFLD)的发生情况,探讨PIH对女性远期NAFLD的影响。方法选择健康体检的3 595例女性作为研究对象,根据PIH患病史,非PIH者3 047例,PIH者548例。比较两者妊娠、分娩特征及体检特征,观察健康体检时NAFLD的检出情况,分析NAFLD发生的影响因素。结果 PIH者分娩前收缩压、舒张压、分娩年龄及腹围均高于非PIH者(P<0.05),而孕周及新生儿体重则低于非PIH者(P<0.05),两者新生儿身长差异无统计学意义(P>0.05)。PIH者年龄、收缩压、舒张压、体质指数(BMI)、三酰甘油(TG)、总胆固醇、空腹血糖(FBG)水平均高于非PIH者(P<0.001),NAFLD发生率也高于非PIH者(P<0.001),而两者低密度脂蛋白胆固醇、尿酸(UA)、高密度脂蛋白胆固醇水平差异无统计学意义(P>0.05)。logistic回归分析结果显示,分娩年龄、新生儿体重、体检时年龄、BMI、腹围、TG、FBG和UA水平是NAFLD发生的影响因素,而PIH并未进入回归方程。结论 PIH与女性远期NAFLD的发生无关。
Objective To compare the incidence of long-term nonalcoholic fatty liver disease (NAFLD) in women with and without PIH and to investigate the effect of PIH on female long-term NAFLD. Methods A total of 3 595 women were selected as healthy subjects. According to the history of PIH, there were 3 047 non-PIH patients and 548 PIH patients. The pregnancy, delivery characteristics and physical examination characteristics of the two groups were compared. The detection of NAFLD during physical examination was observed, and the influencing factors of NAFLD were analyzed. Results Before delivery, PIH had higher systolic blood pressure, diastolic blood pressure, childbearing age and abdominal circumference than those without PIH (P <0.05), while gestational age and newborn weight were lower than those without PIH (P <0.05) No significant difference in body length (P> 0.05). PIH had higher age, systolic blood pressure, diastolic blood pressure, body mass index (BMI), triglyceride (TG), total cholesterol and fasting blood glucose (FBG) than those without PIH Non-PIH (P <0.001). There was no significant difference between the two groups in the levels of LDL cholesterol, UA and HDL cholesterol (P> 0.05). Logistic regression analysis showed that birth weight, birth weight, age at birth, BMI, abdominal circumference, TG, FBG and UA were the influencing factors of NAFLD, but PIH did not enter the regression equation. Conclusion PIH has nothing to do with the occurrence of long-term NAFLD in women.