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目的探讨慢性心衰患者血浆脑钠肽(BNP)变化的临床意义。方法采用荧光免疫分析法对328例慢性心衰患者及50例健康对照者进行血浆BNP水平的测定,同时以彩色多普勒超声心电动仪测定慢性心衰患者左心室舒张末期内径(LVEDD)、左心室收缩末期内径(LVESD)、左心室射血分数(LVEF),并与血浆BNP含量作相关性分析。结果慢性心衰组患者血浆BNP水平明显高于健康对照者(P<0.01),且不同心功能患者之间的血浆BNP含量亦存在显著差异(P<0.01);慢性心衰组患者血浆BNP水平与LVEF、LVESD、LVEDD呈现良好的相关性(r分别为-0.61、0.55和0.59,P均<0.01)。结论BNP是反映慢性心衰患者心室功能的灵敏指标。
Objective To investigate the clinical significance of plasma brain natriuretic peptide (BNP) in patients with chronic heart failure. Methods Plasma BNP levels were measured in 328 patients with chronic heart failure and 50 healthy controls by fluorescence immunoassay. Left ventricular end-diastolic diameter (LVEDD) was measured by color Doppler echocardiography in patients with chronic heart failure. Left ventricular end systolic diameter (LVESD), left ventricular ejection fraction (LVEF), and plasma BNP levels were analyzed. Results Plasma BNP levels in patients with chronic heart failure were significantly higher than those in healthy controls (P <0.01), and plasma BNP levels were also significantly different between patients with different cardiac functions (P <0.01). Plasma BNP levels There was a good correlation with LVEF, LVESD and LVEDD (r = -0.61, 0.55 and 0.59 respectively, all P <0.01). Conclusion BNP is a sensitive indicator of ventricular function in patients with chronic heart failure.