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目的:探讨各种中毒导致急性呼吸窘迫综合征(ARDS)的病因、治疗、预后。方法:分析1998年10月～2002年10月4年间13例ARDS的临床资料。结果:(1)13例ARDS占中毒病例的0.68%;(2)百草枯、有机磷和一氧化碳中毒导致ARDS发生率较高;(3)2例百草枯和2例一氧化碳中毒表现为单相速发型,其余9例表现为双相迟发型,均合并4个以上脏器损伤;(4)所有病例均予祛毒加综合治疗。(5)发生ARDS的死亡率高,与未发生ARDS的中毒而有MODS的中毒比较有显著性差异(P<0.01)。结论:以祛除毒源和综合治疗为主,可改善ARDS患者预后。
Objective: To investigate the causes, treatment and prognosis of acute respiratory distress syndrome (ARDS) caused by various poisoning. Methods: The clinical data of 13 ARDS patients from October 1998 to October 2002 were analyzed. Results: (1) ARDS of 13 cases accounted for 0.68% of the cases of poisoning; (2) Paraquat, organic phosphorus and carbon monoxide poisoning resulted in a higher incidence of ARDS; (3) 2 cases of paraquat and 2 cases of carbon monoxide poisoning showed single phase velocity Hair style, the remaining 9 cases showed delayed type of biphasic, were combined with more than 4 organs injury; (4) All cases are given to remove poison plus comprehensive treatment. (5) There was a high mortality rate of ARDS, which was significantly different from that of MODS without poisoning of ARDS (P <0.01). Conclusion: To eliminate the source of poison and comprehensive treatment can improve the prognosis of patients with ARDS.