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Cerebrovascular disease has been the leading cause of mortality in the world[1]. In China alone, 1.5–2 million new patients are diagnosed with cerebrovascular disease ever year, and 80％–85％ of them suffer from acute cerebral ischemia[2]. The acute cerebral ischemia can lead to anoxia and ischemia of brain tissue and subsequent necrosis or encephalomalacia, resulting in focal or global cerebral injury. At present, the treatment differs by patients and mortality remains to be high. Hence, further study on the molecular mechanism of the disease is essential to further improve the prognosis of the patients.